Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

resulting in efficient tumour cell killing in vitro and in a mouse model. Dysregulated CD4 T cells have been implicated in autoimmune liver disease, but their phenotypes and origin are still unclear.

Researchers at the Johns Hopkins Kimmel Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy have developed ...

Researchers at the Johns Hopkins Kimmel Cancer Center have developed a computer model to help scientists identify tumor-fighting immune cells in patients with lung cancer treated with immune ...

The paper J.S. Rawlings et al., “Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence,” The EMBO Journal, 30:263-76, 2011. Free F1000 Evaluation The finding ...

MSCs inhibit T-cell proliferation through the induction ... which highlights the crucial role of IFNγ in this model 43. However, inhibition of any one of these molecules does not result in ...

A new way to grow T cells in the lab enables them to live longer and better destroy cancer cells in a mouse model of melanoma ...

CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a ...