domain of the T cell receptor (TCR) α and β chains 1. TCR-peptide–MHC (pMHC) class I complexes for which crystal structures have been determined (mouse 2, 2C–dEV8–H-2K b, human 3,4 ...

However, functional analysis and in vivo transfer of MHC multimer-stained cells is hampered by the persistence of T-cell receptor (TCR)–MHC interactions and subsequently induced signaling events.

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

(2023) Facile repurposing of peptide-MHC restricted antibodies for cancer immunotherapy ... Garcia KC. (2022) Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature. 612, ...

“This is just part of the adaptive immune response, this peptide-MHC-T cell interaction,” Karchin said. “For a T cell and a tumor cell to really recognize each other, there are many other ...