The cytokines considered most relevant to the pathogenesis of HF are tumor necrosis factor-a (TNF) and interleukin(IL)-6, and they have been the most extensively studied in this disorder.

have recently published results showing that blockade of Dickkopf-1 (DKK1), a Wnt receptor antagonist, induces fusion of the sacroiliac joints in a tumor necrosis factor (TNF)-driven arthritis model.

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