Medscape26d
TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease
Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.
EurekAlert!3d
PP2A regulates CD8+ T cell effector functions through AKT signaling pathway: implications for immunotherapy
A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...
Hosted on MSN5mon
A potential pathway may guide new therapies for inflammatory bowel disease and other inflammatory diseases
Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...
EurekAlert!10d
TNIP1 knockdown induces the growth arrest and apoptosis of breast cancer cells by activating the NF-κB pathway
Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...
Nature8y
High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons
Palmitate and TNF-α exposure predominantly induced NPY ... these effects potentially occur via the inflammatory IKKβ/NF-κB pathway. Animal experiments were performed with approval of the ...