Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

have recently published results showing that blockade of Dickkopf-1 (DKK1), a Wnt receptor antagonist, induces fusion of the sacroiliac joints in a tumor necrosis factor (TNF)-driven arthritis model.