What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene ...

The fragile structure of p53 gene reveals why this crucial ... mutational spectrum of the transformation-related protein 53 (TP53) gene, which leads to p53 inactivation in many cancers.