Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

Immunostaining images showing differential PK sensitivity of tau aggregates in brain homogenates from IgG-ms- and TTCM2-ms–treated mice. Credit: Science Translational Medicine (2024).