研究整合了遗传学（GWAS P=6.1×10-115）、临床病理学（NFT负荷）和细胞模型证据，提出BIN1异构体（如神经元特异性isoform 1）在AD中可能通过微胶质细胞介导的tau胞外囊泡释放和神经元内tau错误定位参与疾病进程。 BIN1——AD的遗传风险因子 作为AD遗传架构中仅次于 ...

The specific tau isoforms, such as 3-repeat (3R) and 4-repeat (4R) isoforms, and the distinct conformational strains that misfolded tau can adopt are determinants of the molecular and clinical ...

Age-dependent increase in total tau measured in the cerebral spinal fluid (personal communication, reMYND). These transgenic mice overexpress human tau, specifically the 4R/2N isoform, bearing the ...

In the adult human brain, tau exists in six isoforms, each with unique structural properties. These isoforms are produced ...

immunogen = synthetic peptide corresp. to aa 209-224 (K H Q P G G G K V Q I V Y K P V) of human Tau (3-repeat isoform RD3). Region is flanking junction coded by adjacent exons 9 & 11 in the absence of ...

Of the two, p-Tau has emerged as the more specific and robust biomarker — at least in blood samples. Although the ratio of the two isoforms of amyloid-Beta (aB42/40) changes significantly in CSF ...

In the human brain, tau is found in six different isoforms, each with a molecular weight ranging from 48,000 to 67,000 daltons. Patients with neurodegenerative diseases and severe head traumas are ...

Intracellular tau aggregates are constituted by different isoforms and undergo multiple post-translational modifications leading to heterogenous ultrastructural conformations. Not only are they ...