Using a novel quantitative chemoproteomic strategy, a research group led by Prof. Wang Chu from the College of Chemistry and ...

Using human induced pluripotent stem cells (iPSCs), the international team has been able to show that a specific form of the tau protein, known as the 1N4R isoform, is responsible for mediating ...

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction. Alzheimer's & Dementia , 2025 DOI: 10. ...

In this new study, the research team developed a nasal spray with the ability to clear tau proteins from the brains of mice engineered to have human-like Alzheimer's symptoms. The researchers ...