The original total synthesis of a tetracycline by Woodward and co-workers in 1962 stands as an all-time classic in the field 5.Moreover, the general strategy pioneered by this group—the ...

"This finding is not going to change our understanding about the world of antibiotic resistance, but it's a novel kind of mechanism that at least we can start looking for," Vineis says.

Using a so-called ‘lock and key’ mechanism at the cellular level, these drugs lock into a specific part of the bacterial membrane and attack it. Once the bacteria mutate, the antibiotic is ...