Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF binding. One focus of the lab is to study how TFs regulate Mediator structure and function. To do ...

Some things just go together like “rock and roll” and “fish and chips” or, in molecular biology, “transcription factors” and the “nearby genes they regulate.” The standard, simplified story goes like ...

Deep learning and ATAC-seq uncover noncoding variants linked to gene regulation and disease in human liver cells.

In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...