A flood of comparative genomic data is resulting in the identification of human lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives, transgenic introduction of HLS ...

APP 695 SWE mice expressing transgenic human APP with the two-point (Lys 670 →Asn, Met 671 →Leu) 'Swedish' mutation show age-dependent impairments in several histopathological features ...

The integration of this DNA into the mouse's genome results in the expression of new genetic traits, producing a transgenic mouse. (Image: Adapted from National Human Genome Research Institute) ...

is a state-of-the-art facility offering a wide range of services for the production and support of transgenic and gene-edited mouse and rat research models which are instrumental in understanding ...

This APP transgenic overexpresses mutant human APP under the control of the Thy-1.2 promoter, driving neuronal expression. The transgene carries two mutations associated with familial Alzheimer’s ...

Transgene containing human 4-repeat tau cDNA with the R406W mutation containing myc and FLAG tags at N-and C-terminal ends, respectively, and driven by the CaMK-II promoter. Argyrophilic and ...

‘This goat's milk represents one of the first transgenic food products that has the potential to really benefit human health,’ said Professor Jim Murray, who led the study along with Professor ...