But with base editing, we can only engineer transition mutations, such as thymine substituting for cytosine. We therefore miss roughly half the mutations seen in cancer patients. We have begun to ...

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic “marks” in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may ...

The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

Andrew Feinberg, M.D., Bloomberg Distinguished Professor in the Johns Hopkins University schools of medicine, engineering and public health "The transition begins when cells acquire an altered or ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

"This work shows a key role for epigenetic memory in the transition to cancer even without a genetic mutation," says Feinberg. "This transition state is probably a normal way that the pancreas ...