在肿瘤微环境中，调节性T细胞（Tregs）早已被视为抗肿瘤免疫系统的“叛徒”。尽管我们明白Tregs在抑制免疫反应方面的作用，但它们如何具体实现这一点仍然是一个谜。最近，NoyesD等研究者通过对小鼠模型及人类样本进行深入研究，揭示了Tregs如何通过双重机制，即抑制共刺激信号及剥夺白细胞介素-2（IL-2），来导致CD8+T细胞的功能障碍和克隆多样性的受限。

Regulatory T cells (Tregs) have gone from obscurity to rock-star status in the past decade, prompting intense scrutiny—but what exactly are they? Four studies examine this question, delving ...

T细胞作为对抗感染的第一线战士，一直是研究的主要焦点。调节性T细胞（Tregs）是一种特殊的免疫细胞，肩负着在体内维持免疫平衡的艰巨任务。它们必须确保免疫系统既足够强大以对抗感染和癌症，又不会过度反应而攻击身体的正常细胞。Tregs通过控制其他 ...

Lupus is an autoimmune disease where the body's immune system attacks its own tissues and organs, causing inflammation and damaging organs. A new study has now shown that the natural active ingredient ...

Systemic lupus erythematosus, or lupus, is a complex autoimmune disease in which the immune system mistakenly attacks healthy ...

Previous studies on regulatory T-cell (Treg) reconstitution after allogeneic hematopoietic SCT (HSCT) have suggested that, within the GVHD process, imbalance between effector T cells and Tregs may ...

A team has developed scSPOT, a new technique that reveals how immune cells called Tregs simultaneously control the immune system. The team identified key immune cells controlled by Tregs and found ...

Regulatory T cells (Tregs) are specialized immune cells that have a challenging task in the body. They must balance the immune system by making it aggressive enough to fight infection and cancer ...