Mammary gland fibroblasts are highly plastic and transition through distinct states during development and disease. A new ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, ...

胃癌（GC）发病率和死亡率高，严重威胁人类健康。研究人员聚焦 P4HA1 开展研究，发现其在 GC 组织和细胞中高表达，促进癌细胞增殖、转移和干性。这为 GC 治疗提供新方向，有望成为潜在治疗靶点。

From a meeting that celebrates basic research and being "first," a look at 3 data sets on therapies that would break new ...

In cancer and obstructive disease, the ECM has a critical role in pathogenesis. The challenge in these settings will be to find therapies that prevent hyperproliferation and encourage proper ...

The Incucyte ® Live-Cell Analysis System is a fully automated platform for phase contrast and two-color fluorescence imaging, ...

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

Adhesive Interactions Influencing Metastases Integrins are the major extracellular matrix (ECM) receptors, and integrin-mediated adhesive interactions between tumor cells and the components of ...

Mapping a tumor's cellular neighborhood in three dimensions could identify potential targets for personalized cancer therapy.