The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

Two of the most studied forms of plasticity, long-term potentiation (LTP) and long-term depression (LTD), involve both glutamate and GABA (γ-aminobutyric acid) receptors, and it is becoming clear ...

The inhibition of tyrosine kinases blocks the activation of VEGF receptor and platelet-derived growth factor receptor, thereby reducing angiogenesis and vascular leakage. Unlike current anti-VEGF ...

DelveInsight’s, “Colorectal Cancer Pipeline Insight 2025” report provides comprehensive insights about 195+ companies and ...

RET, a transmembrane receptor tyrosine kinase, plays a crucial role in various cellular processes, including embryogenesis and cell development. However, when aberrantly activated due to mutations ...

The US Food and Drug Administration (FDA) has approved Exelixis’ Cabometyx (cabozantinib) to treat advanced neuroendocrine ...

a receptor tyrosine kinase and AD risk factor, rises in both neurons and astrocytes as amyloidosis sets in. In astrocytes, it promotes reactivity and activation of the complement cascade, which turns ...

Using human endothelial cells, they found that ADM inhibited insulin receptor phosphorylation via protein-tyrosine phosphatase 1B, reducing insulin signaling. In vivo, researchers engineered ...