UbiREAD: Cracking the ubiquitin code of protein degradation
Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...
Nature1y
The ubiquitin system
Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...
Scientists Finally Crack Decades-Old Mystery Behind Parkinson's, Paving Way For Treatment
Melbourne-based researchers at the Walter and Eliza Hall Institute (WEHI) at the Parkinson's Disease Research Centre have ...
EurekAlert!5d
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...
EMBO Press8d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
Informationsdienst Wissenschaft4d
Cracking the Code of Protein Degradation
Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...