UbiREAD: Cracking the ubiquitin code of protein degradation
Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...
Nature1 年
The ubiquitin system
Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...
Informationsdienst Wissenschaft4 天
Cracking the Code of Protein Degradation
Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...
EMBO Press8 天
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
EurekAlert!5 天
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct ...
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...