There were no cardiovascular events or edema in either group, indicating that the additive beneficial effect of cilnidipine on albuminuria does not come at the cost of more frequent adverse events.

In another such trial (VALUE), researchers randomized 15,245 hypertensive patients (minimum age, 50; mean BP, 155/87 mm Hg) in 31 countries to receive the angiotensin-receptor blocker valsartan or ...

For the duration of trial 1, 61.0% of patients received valsartan alone, whereas 39.0% received additional antihypertensive agents at some point during the study. In trial 2, 75.8% of patients ...

He noted that ARNIs such as sacubitril/valsartan provided dual benefits ... Bansal also compared cilnidipine and amlodipine ...