服用维生素 D3 一般不会直接导致膝关节疼痛，但在某些特殊情况下，可能会间接地产生影响。这可能与个体差异、服用剂量、潜在疾病、药物相互作用以及其他未知因素有关。 1. 个体差异：每个人的身体对维生素 D3 的反应不同。部分人群可能存在特殊的体质或遗传因素，使得他们在服用维生素 D3 后出现一些不常见的反应，包括膝关节疼痛，但这种情况较为罕见。 2.

Vitamin D3 supplementation was associated with antihypertensive effects without significant between-dose differences among overweight older adults.

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