We have been exploring the potential of the neuromodulator, adenosine, to reduce excessive dopamine signaling that contributes to the development and persistence of psychostimulant abuse. Dopamine’s ...

Adenosine is a short-acting endogenous molecule that is a purine nucleoside. The half-life is 6 seconds. Adenosine receptor activation results in multiple different actions depending on the location.

It all comes down to understanding the adenosine clearance window. Let’s break it down in simple terms. Adenosine is a natural chemical in your body that builds up while you’re awake.

This reaction releases a lot of energy, which the organism can then use to build proteins, contact muscles, etc. The reaction product is adenosine diphosphate (ADP), and the phosphate group either ...