Adenosine is a short-acting endogenous molecule that is a purine nucleoside. The half-life is 6 seconds. Adenosine receptor activation results in multiple different actions depending on the location.

It all comes down to understanding the adenosine clearance window. Let’s break it down in simple terms. Adenosine is a natural chemical in your body that builds up while you’re awake.

The reaction product is adenosine diphosphate (ADP), and the phosphate group either ends up as orthophosphate (HPO 4) or attached to another molecule (e.g. an alcohol). Even more energy can be ...

We have been exploring the potential of the neuromodulator, adenosine, to reduce excessive dopamine signaling that contributes to the development and persistence of psychostimulant abuse. Dopamine’s ...