其激活过程如下：Wnt 蛋白与细胞膜上的 Frizzled（FZD）受体结合，激活低密度脂蛋白受体相关蛋白 5 和 6（LRP5/6）共受体；这一过程触发 Dishevelled（DVL）介导的 β-catenin 破坏复合物（DC）解离，DC 由 AXIN、APC、GSK - 3β 和 CK - 1α 组成，DC 解离后失去降解 β-catenin 的 ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

Figure 6: The mechanism by which WNTs prevent the GSK3-catalysed phosphorylation of axin, APC and β-catenin ... signalling without triggering the WNT signalling pathway. If such drugs can ...

Wnt binds to the Fz receptor and LRP5/6 co-receptor. This activates Dvl to cause the dissociation of Axin from the destruction complex, causing β-catenin to be stabilized and enter the nucleus.

In HCC, mutations in key components of the Wnt pathway, including β-catenin (encoded by CTNNB1), AXIN, and APC, lead to sustained activation of this pathway. This dysregulation drives HCC ...