Thus, understanding the molecular mechanisms driving HCC is essential for developing new therapeutic strategies. A growing body of research highlights the crucial role of the Wnt signaling pathway ...

In addition, Wnt research has covered the spectrum of ... Learning to manipulate this pathway through new low-molecular-weight substances or recombinant or therapeutic molecules is of great ...

ST316, a β-catenin/BCL9 antagonist, demonstrated safety, target engagement, and early antitumor activity in advanced solid ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

The molecular mechanism of planar polarity is understood best in fruit flies, but whether the same genes are at work in vertebrates has been unclear. In the June 1 Development, Alain Dabdoub and ...

Researchers have answered a long-standing question in developmental biology by revealing the driving forces of the massive cell movements that occur during early embryonic development ...

Hypospadias is a widespread congenital disorder, characterized by an abnormal placement of the urethral opening, impacting as ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...