Therefore, a great deal of effort is being invested worldwide in developing therapeutic agents that function by fine-tuning the Wnt pathway. This article describes major milestones that have ...

2017年7月5日，南京医科大学附属淮安第一人民医院神经外科在Oncology Research（中科院四区 IF=2）期刊上在线发表题为 "Overexpression of Protease Serine 8 Inhibits Glioma ...

ST316, a β-catenin/BCL9 antagonist, demonstrated safety, target engagement, and early antitumor activity in advanced solid ...

生长分化因子15（GDF15）作为TGF-β超家族成员，在肝纤维化中发挥重要作用。前期研究表明GDF15表达水平可以预测代谢功能障碍相关脂肪性肝炎（MASH）发病，其血浆水平升高与5-10年后MASH发病显著相关。然而，GDF15在MASH中的表达调控机制尚未完全阐明。2025年1月21日，首都医科大学附属北京友谊医院王皓、通讯作者孔媛媛教授 ...

Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

The Wnt signaling pathway is a conserved network that regulates cell proliferation, differentiation, and migration. It consists of the canonical Wnt/β-catenin pathway and non-canonical pathways ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common ...

(“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company dedicated to developing stenoparib—a differentiated dual PARP/Wnt pathway inhibitor—as a ...