Therefore, a great deal of effort is being invested worldwide in developing therapeutic agents that function by fine-tuning the Wnt pathway. This article describes major milestones that have ...

ST316, a β-catenin/BCL9 antagonist, demonstrated safety, target engagement, and early antitumor activity in advanced solid ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company ...

The Wnt signaling pathway is a conserved network that regulates cell proliferation, differentiation, and migration. It ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

The protocol aims to deepen our understanding of stenoparib’s clinical benefit in a well-defined ovarian cancer patient population while also assessing its potential impact on the Wnt pathway ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

Trial to explore novel combination therapy for patients with recurrent Small Cell Lung Cancer who have failed frontline treatmentFully funded by the U.S. Veterans’ Administration Special Emphasis Pane ...