The concept of 'checkpoints' arose from the discovery of genes in budding yeast that are required for coordinating the progression of cell-cycle events when earlier processes have not been ...

The irreversibility of cell-cycle transitions is commonly thought ... is initiated by Cdk1–CycB complexes in yeasts (Cdk1–Clb5,6 in budding yeast; Cdk1–Cig2 in fission yeast).

Ribosomal translation is the process by which cells synthesize proteins based on the genetic instructions encoded in ...

Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution.