Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

Another result of this research are zinc finger nucleases. These artificial enzymes consist of a sub-unit that recognizes the desired DNA sequence, and a DNA-cutting part of a restriction enzyme.

The monocytic leukemia zinc-finger protein (MOZ) gene is rearranged in t(8; 16)(p11; p13) and inv(8)(p11q13) associated with acute myeloid leukemia. The other fusion partners involved are CBP and ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

Understanding of the DNA-binding characteristics of zinc-finger protein transcription factors has made it possible to design ZFPs to bind to specific target sequences and these designed ZFPs have been ...

Figure 1 Left shows: Two zinc fingers in the DROSHA crystal structure. Right: A partial structure of the Microprocessor complex. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

Shanghai Henlius Biologics Co. Ltd. has synthesized histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) and/or histone acetyltransferase KAT6B (MOZ2; MYST-4) ...

Sangamo Therapeutics Reports Recent Business Highlights and Fourth Quarter and Full Year 2024 Financial Results ...