We now show that NT induces release of extracellular mitochondrial DNA (mtDNA ... p = 0.006), and anti-mitochondrial antibody Type 2 (n = 14; p = 0.001) as compared to normally developing ...

Noteworthy, therefore, was the presence of either high titers of anti-DNA antibodies or very low serum complement levels in a number of patients who had no manifestations of active renal disease.

leading to anti-drug antibodies that can limit how long a treatment will be effective," said Pablo Tebas, M.D., a professor of Infectious Diseases at Penn. "Our DNA-based approach has demonstrated ...

There is an increase in autoantibodies, such as rheumatoid factor and anti-DNA antibodies, with age. Dendritic cells (DCs) are critical in the maintenance of self-tolerance and altered functions ...