尽管冷冻电镜（cryo-EM）技术的进步使已知的膜蛋白与相关脂质的结构数量有所增加，但对于膜蛋白周围脂质的组织方式以及膜蛋白如何影响脂质排列等问题，仍有待深入研究。在此背景下，来自斯洛文尼亚国家化学研究所 ...

This protocol describes the optimization of RNA preparation conditions for cryo-EM structure determination ... Cryo-electron tomography with subtomogram averaging is useful for the structural ...

The University of Colorado Boulder Biochemistry Department's Krios Electron Microscopy facility (BioKEM) offers single particle cryo-EM and cryo tomography of plunge-frozen samples. The BioKEM ...

The interior of a cell captured by cryo-electron tomography imaging and overlayed with three-dimensional reconstructions of mitochondrial inner (pink), outer (purple) and endoplasmic reticulum ...

Mycobacteria are the world's most deadly bacteria --c ausing infectious diseases including tuberculosis (TB), which alone kills more than one million people each year. New drugs to fight these ...

In the rapidly evolving field of structural biology, single particle analysis (SPA) and cryo-electron tomography (cryo-ET) are powerful techniques that allow ... Collectively, these enhancements build ...

Jude Children's Research Hospital used cryo-electron microscopy (cryo-EM) to obtain fine structural details of a human chromatin remodeler in action. The researchers captured 13 structures that ...

Researchers at Pitt have produced the most detailed image to date of a bacteriophage–phage for short–that has allowed them to see for the first time the structural makeup of the part of the phage that ...

It enables ambient temperature and cryo-electron microscopy of single particle or tomography samples to obtain preliminary data prior to more detailed ... and typically creates a gradient in ice ...