Researchers from SRM Institute of Science and Technology, led by Dr. KN Aruljothi, have published a study in ExRNA ...

The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...

Clinicaltrials.gov identifier. RAF, PI3K and the RAL guanine exchange factor (RAL-GEF) were initially identified as essential components of RAS-mediated transformation in rodent cells. Human cell ...

For example, patients diagnosed with non-small cell lung cancer (NSCLC) often receive genomic testing for mutations in genes like KRAS, EGFR and ALK ... role in treatment. PI3K pathway mutations ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

but expression of wild-type EGFR and EGFR * displaced MET from the GAB1–PI3K complex. Downstream signalling did not change, indicating that MET and EGFR act as independent redundant inputs to ...

Despite advancements in EGFR-targeted therapies ... focusing on targeting downstream molecules within the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. Furthermore, the study explores the intricate ...

Much of the current focus has been directed at inhibiting the activation of RAF/MAPK and PI3K/AKT signaling, but clinical trials combining multiple different agents that target these pathways have ...