Discover how an emerging technology called tRNA therapy could become the next big thing in genetic disease treatment.

Transfer ribonucleic acid (tRNA) is a type of RNA molecule that helps decode a messenger RNA (mRNA) sequence into a protein. tRNAs function at specific sites in the ribosome during translation ...

Alltrna’s CEO Michelle Warner said that the approach allows for basket trials that can group patients with different diseases together.

The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But where does translation take place within a cell?

For example, tRNA (transfer RNA) is an adapter molecule that deciphers the genetic code on mRNA (messenger RNA) into a functional product (protein) on the ribosome. RNA research is currently ...

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat hemophilia A. The Cambridge, Massachusetts-based biotech is closing ...

Each tRNA molecule has an anticodon that is complementary to a specific codon on the mRNA. The tRNA binds to its corresponding amino acid and transports it to the ribosome, where it is incorporated ...

Werner held roles at Bristol Myers Squibb, AstraZeneca and Novartis before landing at Alltrna, where she works to develop tRNA-based treatments for a range of diseases.

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

(H) IARS2 mRNA transcription was up-regulated in pancreatic ... ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. IARS2, isoleucyl-tRNA synthetase 2; PDAC, pancreatic ductal adenocarcinoma.

US-based biotechnology company Alltrna is developing transfer RNA (tRNA)-based therapies that aim ... gene editing, or mRNA, ...