DNA containing a repeated nucleosome-positioning sequence was combined with recombinant histones to reconstitute an array of regularly spaced nucleosomes. Cross-linking the nucleosomes with their ...

Since opposite charges attract, the DNA is pulled in toward the histones. A nucleosome is a segment of the DNA wrapped around a core of histones. Here is a view of the double helix -- the subject ...

These findings suggest that viral histones and HFPs may play diverse roles beyond nucleosome formation, with potential functions in viral genome organization and virus-host interactions.

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how ...

The cell's genetic material, DNA, is packaged into tightly wound structures called nucleosomes. The DNA (red) is wound around two sets of core histone proteins (green) to form a kind of bead on a ...

Just the other day I was talking to a researcher on the phone whose work had unexpectedly intersected with nucleosome remodeling. I get the feeling it?s not an ...

Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The ...

A second epigenetic mechanism implicated in learning and memory involves modification of histones, the proteins that DNA wraps around for organization and packaging within the nucleus 3,7. The basic ...