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乙肝病毒核心蛋白变异体 CpF97L:改写乙肝病毒研究格局,助力攻克 ...
通常,含 dsDNA 的衣壳优先分泌为包膜病毒粒子,而含 pgRNA 或单链 DNA(ssDNA)的衣壳留在细胞质中成熟为 dsDNA。但患者中常见的 Cp 突变(如 CpF97L 或 CpI97L)会导致细胞培养实验中分泌高水平含 ssDNA 的病毒粒子。本研究发现,HBV - CpF97L 还能分泌高水平含 RNA 的病毒 ...
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