“That’s why only 5% of these diseases have an approved therapy – most remain overlooked and underserved.” Alltrna’s engineered tRNA technology is designed to read through premature stop codons and ...

First, the ribosome moves along the mRNA in the 5'-to-3'direction, which requires the elongation factor G, in a process called translocation. The tRNA that corresponds to the second codon can then ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Mitochondrial Glu-5'tsRNA-CTC disrupts the binding of mt-tRNALeu and leucyl-tRNA synthetase 2 (LARS2), impairing mt-tRNALeu aminoacylation and mitochondrial-encoded protein translation.