HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat ...

The pioneering research of UC Santa Cruz’s Upasna Sharma to determine how a father’s life experiences and environment can influence the health and wellbeing of his children moves forward with the ...

each must address a specific gene or disease,” said Werner. “That’s why only 5% of these diseases have an approved therapy – most remain overlooked and underserved.” Alltrna’s engineered tRNA ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...

Prokaryotic organisms contain one type of rRNA gene that encodes three distinct ... which is the 3' end of the tRNA, binds to its corresponding amino acid at an attachment site that is also ...

Processing of the primary transcripts involves RNA excision and modification. The tRNA genes mark most of the junctions between mitochondrial protein-coding and rRNA genes. The first step in the ...

A recent study published in the Genes & Diseases journal by researchers at Shanghai Jiao Tong University School of Medicine implicates isoleucyl-tRNA synthetase 2 (IARS2) in promoting the ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments (tRFs). tRFs are created by cleavage of transfer ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...