Processing of the primary transcripts involves RNA excision and modification. The tRNA genes mark most of the junctions between mitochondrial protein-coding and rRNA genes. The first step in the ...

The pioneering research of UC Santa Cruz’s Upasna Sharma to determine how a father’s life experiences and environment can influence the health and wellbeing of his children moves forward with the ...

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive ...

Their findings revealed that these genes play a role in male fertility and in generating small RNA molecules in mature sperm known as tRNA fragments (tRFs). tRFs are created by cleavage of transfer ...

each must address a specific gene or disease,” said Werner. “That’s why only 5% of these diseases have an approved therapy – most remain overlooked and underserved.” Alltrna’s engineered tRNA ...

Some examples of anticodon modifications include: Mutations in tRNA genes or defects in tRNA modifications can lead to various genetic diseases. These alterations can affect the structure and function ...

A recent study published in the Genes & Diseases journal by researchers at Shanghai Jiao Tong University School of Medicine implicates isoleucyl-tRNA synthetase 2 (IARS2) in promoting the ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...