so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific DNA sequences along with the bound proteins. By using enzymes ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

This article explores 6-base genome sequencing and how it is empowering researchers to expand their studies to include both ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...