so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The ...

This article explores 6-base genome sequencing and how it is empowering researchers to expand their studies to include both ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

In their new study, the researchers examined the spatial organization of chromatin, which includes DNA and related structural proteins, in one of the most interesting model organisms in biology ...