This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components ...

The researchers found that Zeb2 acts as a master switch. When the gene is active, it turns macrophages into cancer supporters ...

The researchers found that Zeb2 acts as a master switch. When the gene is active, it turns macrophages into cancer supporters. When silenced, macrophages revert to their natural, cancer-fighting role.

Macrophages, part of the innate immune system, can exhibit a form of immune memory by adjusting their molecular signaling after an infection. This adaptation can either enhance or reduce their ...

Through CRISPR-Cas9 gene editing and single-cell analysis, they zeroed in on a gene named Zeb2.

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health ...