Mewtwo Strikes Back, which has since been remade as a 3D animated film, depicts Mewtwo before it broke free of the lab it was created in, floating in a glass tube, listening to the people around it.

If you want to be the best like Ash Ketchum, you’ll need to prove yourself by defeating all Gym Leaders in Mewtwo. Can you do it? Of course. Capture Pokémon and train them, and soon ...

and leave the laboratory behind. It's a tale as old as Frankenstein (at least), but the familiar story was reimagined with an anthropomorphic edge at the turn of the millennium. For Mewtwo ...