Bile acids are transported in portal blood to the liver where bile acids are taken up by hepatocytes via the Na+-dependent taurocholate co-transporting polypeptide (NTCP) and organic anion ...

Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.

The large arginine side chain at position 158 in mNTCP, which inhibits deep preS1 insertion into the NTCP bile acid pocket, ...