Trajkovic et al. now report that exosome biogenesis requires the sphingolipid ceramide, whereas the ESCRT (endosomal sorting complex required for transport) machinery is only needed for ILVs that ...

Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic ...

More information: Onorina L. Manzo et al, Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects ...

Gao, Y-G., McDonald, J., Malinina, L., Patel, D. J. & Brown, R. E. (2022). Ceramide-1-phosphate transfer protein promotes sphingolipid reorientation needed for ...