再取进展！郑大一附院再发文：发现肾脏疾病治疗新靶点
此前已证实阿霉素（ADR）可诱导小鼠足细胞衰老。为进一步探究这一过程的机制，研究了雷莫丁（Remodelin）处理后肾小球中衰老相关蛋白的变化。蛋白质印迹（WB）分析显示，雷莫丁可减轻阿霉素诱导的 P53、P21、P16 ...
腾讯网6 天
再取进展！郑大一附院再发文：发现肾脏疾病治疗新靶点
并降低了肾小球中 P53、P21 和 P16 的表达水平。为证明这些变化特异性地发生在足细胞中，通过共染 P21 和 P16 与足细胞标志蛋白 WT-1 进行了免疫荧光 ...
Nature1 个月
Systemic Delivery of Tumor-Targeted p53 Gene Therapy Results in Chemo/Radiosensitization
Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...
来自MSN3 个月
Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance
in regulating Tumor Protein p53 (p53) expression in adipocytes and its impact on energy metabolism, body weight gain, and insulin sensitivity. Read the full story here.