Background At least 60% of stroke, 40% of dementia and 35% of late-life depression (LLD) are attributable to modifiable risk ...

Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Correspondence to Dr Ruth Ann Marrie, Internal Medicine, University of Manitoba College of Medicine, Winnipeg, MB R3A 1R9, Canada; rmarrie{at}hsc.mb.ca Pain can be one of the worst symptoms of ...

Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or ...

Loss of nigrostriatal dopaminergic projection neurons is a key pathology in Parkinson’s disease, leading to abnormal function of basal ganglia motor circuits and the accompanying characteristic motor ...

Objective: Parkinson’s disease (PD) is a progressive neurological disorder characterised by a large number of motor and non-motor features that can impact on function to a variable degree. This review ...

The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely ...

Correspondence to Dr Timothy Rittman, Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building, Forvie Site, Addenbrooke's Hospital Site, Robinson Way, Cambridge CB2 0SZ, ...

Dr Paul T Francis, Dementia Research Laboratory, Division of Biomolecular Sciences, Guy’s, King’s and St Thomas’ Schools of Biomedical Sciences, King’s College, St Thomas Street, London SE1 9RT, UK.

Objective To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). Methods 373 patients with ALS (El Escorial definite ...