Tolebrutinib is an oral, brain-penetrant, and bioactive Bruton’s tyrosine kinase inhibitor that modulates peripheral ...

Autoimmune generalized myasthenia gravis is a disease that manifests with fluctuating muscle weakness. Inebilizumab is a ...

Throughout the course of multiple sclerosis, gradually progressive neurologic impairment can occur, which has been called ...

Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib — a ...

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have ...

The National Academy of Medicine and the Journal have partnered to create this series on issues important to health and medicine.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

Is the incidence of acute otitis media increasing or decreasing in the United States? Although the incidence of acute otitis media, and particularly of recurrent and refractory cases, has been ...

The 226 kidney-transplant recipients were bled before transplantation, and the serums tested against lymphocytes of 10 to 40 randomly selected persons. 6 On the basis of these reactions, serums ...