研究结论和讨论部分表明，ProPPr 方法适用于 FFPE 脑组织，能够无偏地发现局部蛋白质组，为 tau 蛋白病的潜在蛋白质组学景观提供有价值的见解，有助于揭示 tau 病理的分子机制。研究发现的这些与 tau ...

Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the ...

然而，此前对于 MAPT 突变导致的 tau 丝结构，尤其是含 3R 和 4R tau 的丝结构，尚未有相关报道。在不同的 tauopathy（tau 蛋白病）中，tau 丝的折叠形式多样，与疾病的关联也较为复杂，这使得深入了解这些疾病的发病机制变得困难重重。为了揭开这些谜团，来自 ...

both neuronal and glial tau accumulation demonstrate 4R-tau in the cerebral cortices. Brain extracts from patients with PSP show a distinctive pattern of tau fragments consisting of a predominant ...

Future Neurology. 2012;7(4):409-421.

These new insights emphasise that the pathological events and processes that lead to the accumulation of phosphorylated tau protein in the brain are best considered as dynamic processes that can ...

Some CBS cases are caused by AD pathology, and some by 4R tauopathy found in FTD. Plasma p-Tau217 can distinguish the two, enabling clinical trials (VandeVrede et al., 2023). VandeVrede plans to test ...

TauRx Pharma's effort to bring a tau-targeting drug for Alzheimer's disease (AD) to market has been a marathon, with a number of setbacks over the years, but the company reckons it may finally be ...

A new study from Mass General Brigham researchers has found faster accumulation of tau-a key indicator of Alzheimer's disease-in the brains of women over the age of 70 who took menopausal hormone ...