Alzheimer's disease may be the most common dementia, but amyloid-beta (Aβ) plaques and tau tangles don't tell the whole story of its complex pathobiology. The disease is defined in part by two ...

Dysfunctional Family. A family tree of tau folds now incorporates two new structures—P301L, P301T (bottom)—and fills in ...

Alzheimer's disease is the most common form of dementia, characterized by the accumulation of amyloid-beta (Aβ) and tau proteins in the brain, leading to cognitive decline. Traditionally ...

A new study has found that women with high levels of β-amyloid (Aβ), a protein linked to Alzheimer’s disease, experience ...

While both sexes show similar levels of Aβ burden, studies indicate that women may be more susceptible to tau pathology, a protein linked to neurodegeneration and cognitive decline. Previous ...

A study in Alzheimer's & Dementia, a leading journal in dementia research, has demonstrated the high accuracy of plasma ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

To record the trends in beta-amyloid (Aβ) and tau protein accumulation, PET scans were conducted over a median of 4.5 years and 3.5 years, respectively, and imaging included the frontal ...

NFTs, which are composed of misfolded tau proteins, represent a key outcome of a dynamic process, much like Aβ plaques are the outcome of the amyloid cascade. However, the question of whether Aβ ...

Proteolytic processing of APP. Aβ plaques are accumulations of molecules in the extracellular space of the brain. The principal proteinaceous component of the plaques is the Aβ peptide ...

In vivo imaging of tau pathology will provide new insights into tau deposition in the human brain, thus facilitating research into causes, diagnosis and treatment of major dementias, such as ...