Its ability to bind Fc receptors on phagocytic or other lytic effector cells enables the initiation of antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is a cell-mediated immune ...

Table 1. The types and characteristics of FcγRs. Source: Sino Biological Inc. To mediate antibody-dependent cellular cytotoxicity (ADCC), NK cells recognize cell-bound antibodies via CD16A ...

Figure 1: Antibody design to improve homogeneity and ... and associated with enhanced or silenced effector functions (ADCC or complement-dependent cytotoxicity) are being investigated in clinical ...

In RTX-003, a CD25 T reg cell-targeting program, RubrYc used MEMs to identify epitopes and antibodies that enhance antibody directed cellular cytotoxicity (ADCC). This results in T reg cell ...

Data were summarized with the search of 'colorectal' and 'antibody' as of August 2012 at ClinicalTrials.gov [202]. EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors ...

Monoclonal antibody (mAb)-based immunotherapy is an ... mAb therapy involves a range of mechanisms, including ADCC, complement-dependent cytotoxicity and interference with receptor–ligand ...

DelveInsight's Biologics Drug Substance Manufacturing Market Insights report provides the current and forecast market ...

and antibody dependent cellular phagocytosis (ADCP). Hyaluronidase increases permeability of the subcutaneous tissue by depolymerizing hyaluronan, a polysaccharide found in the extracellular matrix.

a bispecific structure which leverages PD-L1 as an anchor in the tumor microenvironment (TME), and enhanced antibody-dependent cellular cytotoxicity (ADCC) to direct killing of PD-L1-positive ...