Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly ...

These glia-derived neurons share properties with the bipolar, amacrine and retinal ganglion-cell lineages. Adult Müller glia re-enter the cell cycle after AAV-borne expression of proneural genes Ascl1 ...

研究针对小细胞肺癌（SCLC）治疗难题，探究转录因子共表达机制，发现 ASCL1 和 NEUROD1 共表达致死，为治疗提供新方向。 小细胞肺癌（Small Cell Lung Cancer，SCLC）堪称人类癌症中的 “狠角色”，它占所有肺癌病例的 15% 左右，却因其独特的生物学特性和缺乏有效的 ...

Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different ...

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NASHVILLE, Tenn. (WSMV) - Vanderbilt University Medical Center will lead a massive project aimed at discovering therapeutic antibodies through the use of Artificial Intelligence. Therapeutic ...

The advent of effective antiretroviral therapy (ART) has increased the lifespan of many people living with HIV. As a result, ...

The fixed cells were permeabilized with 0.2% Triton X-100 in PBS for 10 min, blocked with 2% BSA in PBS for 1 h at RT, and then incubated overnight at 4°C with primary antibodies including Map2 ...

1Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, ...

Sections were next incubated with 10% (v/v) normal horse serum prepared in PBS containing 1% (v/v) Triton-X-100 for 30 min, followed by overnight incubation at 4°C with primary antibodies (see ...

多阳性肿瘤细胞（MPTC）：超过 10% 的肿瘤细胞共表达多个转录因子（如ASCL1+ NEUROD1+），尤其在 ASCL1 亚型（SCLC-A）中富集。这些细胞表现出高增殖 ...